Scientists discovered three subtypes of a food allergy disorder, according to a study published on May 2, 2018.
This study was conducted by the scientists at Cincinnati Children’s Hospital Medical Center. The three distinct subtypes of eosinophilic esophagitis (EoE), which is an emerging food allergy disorder, was uncovered by the scientists. This study could lead to the development of medicines that could treat this disorder. This study was published online in The Lancet Gastroenterology & Hepatology.
Each of the three subtypes or endotypes were found to be associated with different clinical features and molecular pathways. Molecular profiling was advantageous over the conventional microscopic analysis, which is a traditional approach of studying biopsy specimens. Biopsies of 185 children and adults at 10 sites were studied by the researchers. On analyzing various structural and molecular features, endotypes that were consistent across children and adults were identified and were independent of the number of eosinophils in each sample. The three identified endotypes ranged from mild to severe.
Normal cellular components of the blood are called as Eosinophils, however, too much production of eosinophils could cause a variety of eosinophilic disorders. These disorders involve chronic inflammation and result in damage of tissues.
Dr. Rothenberg, said, “This is an important stride forward for the allergy and gastroenterology fields. With emerging new therapies for allergic diseases, including a new class of anti-eosinophil drugs, as well as anti-inflammatory biological agents that block specific component of allergic inflammation, this is good news for patients, as this brings the field one step closer to personalized and precision therapy.”