Pentylone and Methylone: A structural comparison of these new psychoactive substances

New psychoactive substances, compounds structurally similar to already legislatively controlled illicit drugs recently appearing on the drug scene with increasing frequency, pose an increasing global problem. The EU Early Warning System for NPS currently monitors over 670 substances, with 51 reported in 2017 for the first time and 101 in 2014. In addition, the total

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Vibrational spectroscopy of Synthetic Cathinones

Since methylone and pentylone are in the cathinone family, they can be enantiomerically resolved by several different methods including, for example, capillary electrophoresis, supercritical fluid chromatography, and HPLC. However, only some methods from this list can provide pure enantiomers in preparative amounts of the milligram to gram scale. The most prominent method for the separa-

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Vesicular Monoamine Transporter 2 (VMAT2) Protects against Methylone and Pentedrone Toxicity

The enantioseparation of two cathinone homologues— methylone and pentylone—by HPLC with UV–Vis detection has been successfully carried out using different methods of chiral separation for individual substances. Furthermore, a detailed structural analysis of both drugs of abuse has been achieved by the methods of electronic and vibrational spec- troscopy, specifically conventional UV and IR absorption

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